The Anti-PSD95 Monoclonal Antibody from MyBioSource.com is a Mouse Monoclonal antibody to DLG4, HUGL, Lgl, Lgl1, LLGL, LLGL1, PSD95, and SAP90. This antibody recognizes Human antigen. The Anti-PSD95 Monoclonal Antibody has been validated for the following applications: Immunocytochemistry, and Western Blot.
Description
Postsynaptic Density Protein 95 (PSD95), also known as Synapse Associated Protein 90kDa, is a member of the membrane-associated guanylate kinase family of proteins. PSD95 is a scaffolding protein involved in the assembly and function of the postsynaptic density complex. This family of proteins consists of N-terminal variable segments followed by three amino-terminal PDZ domains, an upstream SH3 domain, and an inactive carboxy-terminal guanylate kinase domain. The first and second PDZ domains localize NMDA receptors and K+ channels to synapses, and the third binds to neuroligins, neuronal cell adhesion molecules. PSD95 also binds to neuronal nitric oxide synthase. PSD95 is implicated in experience-dependent plasticity and plays an indispensable role in learning. Mutations in PSD95 are associated with autism